产品货号：
GS4414
中文名称：
重组大鼠IFN-γ
英文名称：
Recombinant Rat Interferon-gamma
产品规格：
20μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 15.5kDa,a single non-glycosylated polypeptide chain containing 134 amino acids.
储存条件：冷冻（-20℃）
概述
Interferon-gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.It shares high sequence indentity with mouse IFN-γ(86%).IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组大鼠IFN-γ，IFN-γ, Rat，Recombinant Rat Interferon-gamma
储存条件：冷冻（-20℃）
概述
Interferon-gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.It shares high sequence indentity with mouse IFN-γ(86%).IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by an anti-viral assay using murine L929 cells infected with encephalomyocarditis(EMC)virus is less than 0.1ng/ml,corresponding to a specific activity of>1.0×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 1×PBS,pH 7.4,1mMDTT,5%Trehalose and 0.05%Tween-80. |
| 内毒素 | Less than 0.1 EU/μg of rRtIFN-γ as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in 10 mM HAc to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | QGTLIESLES LKNYFNSSSM DAMEGKSLLL DIWRNWQKDG NTKILESQII SFYLRLFEVL KDNQAISNNI SVIESHLITN FFSNSKAKKD AFMSIAKFEV NNPQIQHKAV NELIRVIHQL SPESSLRKRK RSRC |
相关搜索：重组大鼠IFN-γ，IFN-γ, Rat，Recombinant Rat Interferon-gamma